The core curriculum consists of 22 credits focusing on a variety of topics related to clinical and translational research. Completion of these 22 credits is required for both the Certificate and Master’s programs in Clinical and Translational Research.
Instructor(s):Lucy Skrabanek, PhD
In this course, we focus on the proliferation of genomic data, and how it can be used to develop more accurate diagnoses, more rational disease prevention strategies, better treatment selection, and the development of novel therapies. We also explore the challenges posed by large data sets, both analytical and statistical. Finally, the unique privacy and ethical implications that arise from genomics data are discussed.
Principles of Clinical & Translational Pharmacology
This course is designed to present basic principles for understanding the rationale behind development of drug therapy with consideration of the factors involved in individual variability, pharmacokinetics, and pharmacogenomics. Topics include: dose-response, drug efficacy and potency, drug absorption, distribution, metabolism and excretion, effect of liver and kidney disease on dose-response, drugs in the young, the elderly, and pregnancy. The pre-requisite Pharmacology and Drug Development online module (Canvas), needs to be completed prior to this in-person course.
Research Grant Writing, Part 1
This workshop is designed as the first part of a 2 part series presented over 2 days during the Fall semester. The Fall section describes the different kinds of NIH grants, resources for applying (at WCM, as well as NIH provided resources), information about budgets and the NIH study section, and an introduction to the approach to writing a grant. An interactive exercise integrated into the workshop provides an opportunity for peer and expert feedback to help students develop a clear research question that leads to more successful development of specific aims for a grant. This course is offered over two three hour sessions. Upon conclusion of this course CTSC trainees will earn 1 core credit towards the MS degree.
Research Grant Writing, Part 2
This workshop is designed as the second part of a 2 part series presented over 2 days during the Spring semester. The Spring semester dives into the nuts and bolts of the different components of the grant itself, the review process, during which CTSC alums are invited to describe their review and resubmit processes. Trainees also receive one-on-one consultations with the instructor to review red-lined written feedback of components of their grants. Students completing the course will understand the fundamental components of a grant proposal such as the abstract or summary, background and significance, specific aims/goals and objectives, project design and methods. They will also increase the skills needed to develop competitive grant proposals. Students have the opportunity to draft grant proposals among peers. Upon conclusion of this course CTSC trainees will earn 1 core credit towards the MS degree.
Introduction to Biostatistics in Clinical Research
Instructor(s):Paul Christos, DrPH, MS, MPH
This course is an introduction to the fundamental statistical issues in the design of clinical research studies. Its primary emphasis is on understanding the design and analytic methods of clinical research from a statistical perspective.
Clinical Trials Design and Analysis
Instructor(s):Marshall Glesby, MD, PhD and Timothy Wilkin, MD, MPH
This course will provide an overview of how to design, conduct, and analyze clinical trials. Completion of this course will lead to an understanding of the theoretical and practical aspects of clinical trials related to the strengths and limitations of randomized clinical trials; theoretical and practical aspects of randomization, stratification, and blinding; challenges of designing and implementing single center and multi-center clinical trials; major issues in the analysis of clinical trials; role of clinical trials in the drug development process; and investigator’s roles and responsibilities in conducting clinical trials.
Pre-requisite: Introduction to Biostatistics in Clinical Research
Data Management for Clinical Research
Instructor(s):Elizabeth Wood, MS
This course is designed to familiarize individuals with computer technologies and procedures essential in current clinical research including database creation and management, data security, and basic medical informatics.
Ethical, Social and Legal Issues in the Responsible Conduct of Research
Instructor(s):Inmaculada de Melo-Martin, PhD, MS
This course is an examination of various ethical aspects that arise when conducting biomedical research. In order to evaluate such ethical concerns, students will review and critically analyze the philosophical underpinnings of current guidelines and regulations for the responsible conduct of research. Pre-requisite: Tri-Institutional Responsible Conduct of Research (offered in fall).
Foundations of Clinical Research
Instructor(s):Alvin Mushlin, MD
The goal of this course is to provide an overview of the methodological foundations for research involving human subjects, while gaining an understanding of core epidemiological concepts, theory and applications of commonly used biostatistical methods, and investigative methods of clinical interventions.
Foundations of Epidemiology
Instructor(s):Patricia Cassano, MPH, PhD
Through a combination of video-conferencing and live lectures, this course will provide students with an introduction to basic and intermediate epidemiologic methods to build the foundation for further work in epidemiology either as practicing epidemiologists or as sophisticated users of epidemiologic information.
Molecular Biology and Genetics in Clinical Research
Instructor(s):Yuan-Shan Zhu, MD, PhD
This course is designed to introduce basic concepts and principles of molecular biology and molecular genetics; basic technology of molecular biology in translational research; contemporary concepts and technology of molecular genetics and molecular biology as related to clinical research and clinical medicine.
Tri-Institutional Responsible Conduct of Research
Instructor(s):Randi Silver, PhD and Helene Brazier-Mitouart, PhD
This course will inform trainees of federal, state, and institutional policies, regulations, and procedures, and provide trainees with critical analysis and problem-solving skills for ethical decision-making.